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Analysis of the US Anthrax Vaccine (AVA)
The Anthrax Vaccine Adsorbed (AVA), commercially known as BioThrax, remains the only FDA-licensed human anthrax vaccine in the United States. While its primary role is to protect high-risk personnel—such as laboratory workers and military members—from Bacillus anthracis, its history and formulation provide a unique case study in vaccine evolution and biodefense strategy.
Mechanism and Formulation
The AVA is a cell-free filtrate vaccine derived from an avirulent, non-encapsulated strain of anthrax. Unlike live-attenuated vaccines used in other regions, AVA does not contain live bacteria. Its primary immunogenic component is the Protective Antigen (PA).
Action: The vaccine stimulates the production of antibodies that neutralize the PA protein. Since PA is the "key" that allows anthrax toxins to enter host cells, neutralizing it prevents the onset of the disease’s lethal effects.